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Metabolic Diseases
 

Metabolic diseases are orchestraed from multiple factors and involved in multiple organs in the body. First Flight Biosciences offers a variety of animal models of metabolic diseases including diabetes, dyslipidemia and obesity. These include both diet-induced and genetic disease models; each model has its own features mimicking human diseases. Thus selection of the appropriate disease model based on the mechanism of action of test agent is critical for ensuring the success of the study. Our seasoned leaders in the field will tailor the study design to individual client's needs.
 
Diabetes
 
High fat diet (60% kcal)-induced obesity in mice (DIO mice, growing or established)
Mice (ob/ob, db/db)
Rats (male ZDF, female ZDF)
High fat-fed guinea pigs
Rhesus monkeys (aged, diet-induced)
Readouts: fasting plasma glucose, insulin, HbA1c, oral glucose tolerance test (OGTT)
 
Obesity
 
DIO mice
ob/ob mice, db/db mice
Aged CD-1 mice (retired breeders)
Rats (DIO, fa/fa)
Readouts: Body weight, food intake, fat pad content
 
Dyslipidemia
 
High fat diet/high cholesterol/high fructose diet models in rodents, guinea pigs, hamsters, and monkeys
Readouts: TPC, LDL-C, HDL-C, TG
 
Metabolic syndrome
 
High fat diet/high cholesterol/high fructose diet models in spontaneously hypertensive rats (SHR)